ANALYSIS OF DOSAGE INSTRUCTIONS IN PACKAGE INSERTS FOR VETERINARY ANTIBACTERIAL MEDICATIONS AND IDENTIFICATION OF POTENTIAL RISKS OF BACTERIAL RESISTANCE
DOI:
https://doi.org/10.25110/arqvet.v29i1.2026-12684Palavras-chave:
Animals, Antibiotics, Microbial resistanceResumo
Veterinarians must follow several criteria before prescribing antibacterials, and one fundamental step is selecting the correct dosage from specialized literature. Occasionally, professionals use the dosage recommended in the package insert, but several report discrepancies between the package insert and the dosage recommended in the literature. Thus, the aim of this study was to compare the dosage presented in package inserts of antibacterials from the veterinary line with the dosage recommended in the updated scientific literature. Package inserts of all antibacterials produced by laboratories associated with the National Union of Animal Health Products Industry (SINDAN) indicated for systemic use in dogs, cats, horses, and cattle were analyzed. The percentage of observations with inserts showing dosage concordant with the consulted reference literature was 50.0% for dogs, 54.2% for cats, 3.8% for horses, and 23.6% for cattle. Of the total observations of veterinary line antibacterials produced by SINDAN-affiliated laboratories, 32% present a dose and interval concordant with the consulted literature, which may favor the expected therapeutic effect; 35% combine a dose below and/or an interval above the reference, which may favor bacterial resistance, a relevant issue for public health; 5% combine a dose above and/or an interval below the reference, which may cause iatrogenic intoxication; and 28% present other combinations, with an undefined effect. These possible consequences were not evaluated directly in this study. Most package inserts of antibacterials from the veterinary line produced by SINDAN-affiliated laboratories in Brazil show divergences in posology compared with the consulted reference literature. The most frequent type of divergence identified was a combination of dose below and/or interval above the reference, a pattern that could favor bacterial resistance if this association is confirmed by studies directly assessing this outcome.
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Copyright (c) 2026 Fransael Franklyn Araújo da Silva, Camila Mariane Sawasa, Mariana Moratelli, Luiza da Rosa Robusto, Ana Caroline Schwingel Wust, Júlia Roberta Cupchinski Rossetto; Erica Cristina Bueno do Prado Guirro
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
