THE ASSOCIATION OF PROCALCITONIN, LACTATE, WBC COUNT, AND INTERLEUKIN-10 MAY BE HELPFUL IN THE EARLY DIAGNOSIS OF SEPSIS IN BRAZILIAN PATIENTS

Autores

DOI:

https://doi.org/10.25110/arqsaude.v29i3.2025-12124

Palavras-chave:

Procalcitonin, Interleukin-10, Interleukin-6, Sepsis

Resumo

Introduction: Sepsis is a set of clinical symptoms resulting from inflammation and infection. Several biomarkers are used for early diagnosis and improved management of sepsis. Objectives: This study evaluated the performance of procalcitonin (PCT), interleukin-10 (IL-10), interleukin-6 (IL-6), and classic inflammatory markers in hospitalized patients with suspected sepsis. Sixty-one patients were assessed. The participants were monitored over a three-day period: baseline (Day 0, D0), 24 hours (Day 1, D1), and 48 hours (Day 2, D2). The hospital’s clinical team classified them as “sepsis” or “non-sepsis”. Results: On the first day (D0), PCT, lactate, leukocyte count, IL-10, and IL-6 were elevated in patients with sepsis compared to those without. On Day 1, all of these biomarkers remained elevated in the sepsis group except for IL-6. By Day 2, none of the parameters differed between the sepsis and non-sepsis groups. AUC analyses demonstrated that PCT, lactate, leukocyte count, and IL-10 could discriminate between sepsis and non-sepsis patients, with IL-10 showing the best sensitivity and specificity at D0 and D1. Conclusion: When combined, the biomarkers performed better in diagnosing sepsis in the Brazilian population.

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Biografia do Autor

Cristiane Alves da Silva Menezes, Universidade Federal de Minas Gerais

Doutorado, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Victor Hugo Ferreira Gomes, Universidade Federal de Minas Gerais

Acadêmico do curso de Farmácia da Universidade Federal de Minas Gerais.

Fernanda Rocha de Freitas, Universidade Federal de Minas Gerais

Metre, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Simone Martins Gonçalves, Hospital Madre Tereza

Mestre, Laboratório de Patologia Clínica, Hospital Madre Tereza, Belo Horizonte, MG, Brasil.

Pâmela Santos Azevedo, Universidade Federal de Minas Gerais

Mestre, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Edna Afonso Reis, Universidade Federal de Minas Gerais

Doutorado, Departamento de Estatística, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Ieda de Fátima Oliveira Silva, Universidade Federal de Minas Gerais

Doutorado, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Ana Paula Lucas Mota, Universidade Federal de Minas Gerais

Doutorado, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

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Publicado

10-10-2025

Como Citar

MENEZES, Cristiane Alves da Silva; GOMES, Victor Hugo Ferreira; FREITAS, Fernanda Rocha de; GONÇALVES, Simone Martins; AZEVEDO, Pâmela Santos; REIS, Edna Afonso; SILVA, Ieda de Fátima Oliveira; MOTA, Ana Paula Lucas. THE ASSOCIATION OF PROCALCITONIN, LACTATE, WBC COUNT, AND INTERLEUKIN-10 MAY BE HELPFUL IN THE EARLY DIAGNOSIS OF SEPSIS IN BRAZILIAN PATIENTS. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 29, n. 3, p. 1231–1248, 2025. DOI: 10.25110/arqsaude.v29i3.2025-12124. Disponível em: https://www.revistas.unipar.br/index.php/saude/article/view/12124. Acesso em: 5 mar. 2026.

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v. 29 n. 3 (2025)

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