PROGNOSIS AND OUTCOMES OF PREGNANT WOMEN WITH COVID-19: A SYSTEMATIC REVIEW AND META-ANALYSIS

Autores

DOI:

https://doi.org/10.25110/arqsaude.v29i3.2025-11921

Palavras-chave:

Pregnancy outcome, Communicable Diseases, SARS-CoV-2, COVID-19, Maternal death, Neonate

Resumo

Objective: This systematic review aimed to analyze whether COVID-19 represents a risk factor for preeclampsia, preterm birth, maternal death, neonatal death, and admission of neonates to the Intensive Care Unit (NICU). Data Sources: Searches were performed in Embase, PubMed, and CENTRAL. Study Selection: Analytical observational studies whose subjects were pregnant women with confirmed COVID-19 were included. Data Extraction: Three reviewers extracted all relevant data from the studies selected for inclusion using a standardized form previously agreed upon by the team. Data pertaining to the studies and clinical outcomes were collected. Results: Twenty studies were included in the systematic review and the meta-analysis. Over 125.000 subjects were included, among them, over 5.000 positive for COVID-19. The meta-analysis showed a significant association between COVID-19 and preterm delivery and maternal death. It was also associated with cesarean delivery, preeclampsia/eclampsia, and emergency cesarean. Conclusion: Patients who are present with COVID-19 infection warrant careful clinical and obstetrical vigilance due to their higher risk of adverse outcomes and measures to reduce the risk for patients and fetuses.

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Biografia do Autor

Max Medeiros Mendonça e Carvalho, University of Brasília

Medical Doctor. Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília-DF, Brazil.

Maria Luísa Lima Pires Ferreira Correa, Uninovafapi University Center

Medical Doctor. Faculty of Medicine, Uninovafapi University Center, Teresina-PI, Brazil.

Vitória Regina Nunes Maia, Federal University of Western Bahia

Medical Doctor. Medical School, Center for Biological and Health Sciences, Federal University of Western Bahia, Barreiras-BA, Brazil.

Mila Silva Cunha, University of São Paulo

Graduated in pharmacy. Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Bruna Gomes Noronha, Ribeirão Preto University’s

Medical Doctor. Faculty of Medicine, Ribeirão Preto University’s, Ribeirão Preto – SP.

Silvia Aparecida Oesterreich, Federal University of Grande Dourados

PhD in Sciences. Faculty of Health Sciences, Federal University of Grande Dourados, Dourados-MS, Brazil.

Marina Meirelles Paes, Federal University of Western Bahia

PhD in in Natural Sciences. Research Group on Development of Pharmaceutical Products (P&DProFar), Center for Biological and Health Sciences, Federal University of Western Bahia, Barreiras-BA, Brazil.

Gustavo Roberto Villas-Boas, Federal University of Western Bahia

PhD in Health Sciences (Pharmacology). Research Group on Development of Pharmaceutical Products (P&DProFar), Center for Biological and Health Sciences, Federal University of Western Bahia, Barreiras-BA, Brazil.

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07-10-2025

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MENDONÇA E CARVALHO, Max Medeiros; CORREA, Maria Luísa Lima Pires Ferreira; MAIA, Vitória Regina Nunes; CUNHA, Mila Silva; NORONHA, Bruna Gomes; OESTERREICH, Silvia Aparecida; PAES, Marina Meirelles; VILLAS-BOAS, Gustavo Roberto. PROGNOSIS AND OUTCOMES OF PREGNANT WOMEN WITH COVID-19: A SYSTEMATIC REVIEW AND META-ANALYSIS. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 29, n. 3, p. 1157–1184, 2025. DOI: 10.25110/arqsaude.v29i3.2025-11921. Disponível em: https://www.revistas.unipar.br/index.php/saude/article/view/11921. Acesso em: 5 dez. 2025.

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v. 29 n. 3 (2025)

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